Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Repaglinide is a meglitinide: like the sulfonylureas, it closes potassium channels in the insulin-making beta cells of the pancreas, but it acts quickly and briefly, so it is taken with meals to cover the rise in blood sugar after eating. It is used for type 2 diabetes. It is sold as Prandin and NovoNorm, among other names.
Repaglinide is taken into the liver by the transporter SLCO1B1 and broken down by CYP2C8 and CYP3A4. The SLCO1B1 variant rs4149056 raises its levels markedly, and some CYP2C8 versions change them too. Studies have also looked at diabetes genes such as KCNQ1, KCNJ11 and IGF2BP2 for how well it lowered blood sugar. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Repaglinide. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLCO1B1 rs4149056: Level 3. Efficacy. 2.
SLCO1B1 rs2306283: Level 3. Other. 1.
KCNJ11 rs5219: Level 3. Efficacy: Diabetes Mellitus, Type 2. 1.
CYP2C8 rs10509681: Level 3. Other. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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