Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Glimepiride is a sulfonylurea: it closes potassium channels in the insulin-making beta cells of the pancreas, which makes them release more insulin and lowers blood sugar. It is used for type 2 diabetes, often with metformin. It is sold as Amaryl, among other names.
The US FDA lists G6PD for glimepiride, because sulfonylureas can cause haemolysis, the breakdown of red blood cells, in people with G6PD deficiency. Glimepiride is broken down mainly by CYP2C9, and studies have looked at CYP2C9 and at KCNJ11 and ABCC8, which make the channel it closes, for blood sugar response and low blood sugar, with weaker evidence. There is no CPIC or DPWG guideline.
Clinical guidelines that name a gene for Glimepiride. They sort people into groups by the gene copies they carry.
US FDA: G6PD. Variable · Deficient with CNSHA · Deficient.
Every published finding on gene variants and Glimepiride. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NOS1AP rs10494366: Level 3. Toxicity: Diabetes Mellitus, Type 2, Hypoglycemia. 1.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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