Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Regorafenib is a targeted cancer medicine, a multi-kinase inhibitor closely related to sorafenib, that blocks VEGF receptors, TIE2, KIT, RET, RAF and others. It is used for advanced bowel cancer after other treatments, gastrointestinal stromal tumours after imatinib and sunitinib, and liver cancer after sorafenib. Liver injury and hand-foot skin reactions are known side effects. It is sold as Stivarga.
Regorafenib is broken down by CYP3A4 and UGT1A9 into active products. The gene study listed looked at KDR, the gene for VEGF receptor 2, for side effects. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Regorafenib. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
KDR rs4864950: Level 3. Toxicity: Drug Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Apatinib (Tyrosine Kinase Inhibitors)
Gilotrif (Tyrosine Kinase Inhibitors)
Gleevec (Tyrosine Kinase Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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