Raloxifene (Evista)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Raloxifene

What it is

Raloxifene is a selective oestrogen receptor modulator (SERM): it acts like oestrogen on bone, preserving bone density, but blocks oestrogen in breast and womb tissue. It is used to treat and prevent osteoporosis after the menopause and to lower the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk. It is sold as Evista, among other names.

How genes come into it

Raloxifene is cleared mainly by the enzymes UGT1A1 and UGT1A8, and studies have linked UGT1A1 variants, including the *28 version behind Gilbert's syndrome, to its blood levels. Others looked at the oestrogen receptor gene ESR1, COMT and ZNF423 for effects on bone and breast cancer risk. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Raloxifene. Upload your DNA file to see which of these rows apply to you.

Rated evidence (6 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

UGT1A1 UGT1A1*1, UGT1A1*28: Level 3. Metabolism/PK: Osteoporosis. 2.

rs10030044: Level 3. Efficacy: Breast Neoplasms. 1.

ZNF423 rs8060157: Level 3. Efficacy: Breast Neoplasms. 1.

ESR1 rs11543791: Level 3. Efficacy: Menopause, Schizophrenia. 1.

Metabolism (1 finding)

Studies of how quickly the body processes this medication.

UGT1A8 UGT1A8*1a, UGT1A8*2, UGT1A8*3: UGT1A8 *1a/*3 (assigned as poor metabolizer phenotype) is associated with increased metabolism of raloxifene in women as compared to UGT1A8 *1a/*1a + *1a/*2 + *2/*2 (assigned as intermediate metabolizer and normal metabolizer phenotype) .

Response (8 findings)

Studies of how well it worked in people carrying a variant.

COMT rs4818: Genotype CG is associated with increased clinical benefit to raloxifene in people with Schizophrenia or Schizoaffective disorder as compared to genotype CC.

COMT rs737865: Genotype AG is associated with increased clinical benefit to raloxifene in men with Schizophrenia or Schizoaffective disorder as compared to genotype AA.

COMT rs737865: Genotype AA is associated with increased clinical benefit to raloxifene in men with Schizophrenia or Schizoaffective disorder as compared to genotype AG.

ESR1 rs11543791: Genotype CC is associated with decreased response to raloxifene in women Menopause and Schizophrenia as compared to genotypes CT + TT.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Tamoxifen (SERMs)

Actonel (Bisphosphonates)

Advil (NSAIDs)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

Back to Medications

Content updated September 2026.

ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.

Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026

Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com