Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pyrimethamine blocks dihydrofolate reductase in parasites, so they cannot make DNA. Combined with sulfadiazine and folinic acid it is the main treatment for toxoplasmosis, including in people with HIV and in pregnancy; with sulfadoxine (SP, Fansidar) it is used for malaria prevention in pregnancy and in children. It is sold as Daraprim.
Pyrimethamine is broken down in the liver. The gene studies listed looked at G6PD in people receiving sulfadoxine-pyrimethamine, because the sulfonamide partner can cause haemolysis in G6PD deficiency. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Pyrimethamine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
G6PD rs1050828: Level 3. Toxicity: Malaria, Malaria, Falciparum. 1.
G6PD;IKBKG rs1050828: Level 3. Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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