Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pyrazinamide (PZA) is an antibiotic used only against tuberculosis. It is turned into pyrazinoic acid inside the bacteria, which works best in the acidic environment where dormant tuberculosis bacteria hide. It is part of the standard first two months of treatment, which shortens the total course. Liver injury and raised uric acid are its main side effects.
Pyrazinamide is broken down by amidase and xanthine oxidase, and studies have looked at AOX1 for its clearance. Most gene studies listing it concern liver injury during combined tuberculosis treatment, where NAT2, the gene that matters for isoniazid, and GST genes were studied; the link to pyrazinamide itself is uncertain. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Pyrazinamide. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TNF rs1800629: Level 3. Toxicity: Toxic liver disease, Tuberculosis. 2.
CYP2C9 rs9332096: Level 3. Toxicity: Maculopapular Exanthema, Tuberculosis. 2.
NAT2 rs1041983: Level 3. Toxicity: Toxic liver disease, Tuberculosis. 1.
CYP2B6 CYP2B6*1, CYP2B6*6: Level 3. Toxicity: Tuberculosis. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Isoniazid (Antimycobacterials)
Myambutol (Antimycobacterials)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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