Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Propofol is the most widely used intravenous anaesthetic: it strengthens GABA signalling and puts people to sleep within seconds, and they wake up quickly once it is stopped. It is used to start and maintain general anaesthesia, for sedation during procedures such as endoscopy, and in intensive care. Its milky appearance comes from the fat emulsion it is dissolved in. It is sold as Diprivan, among other names.
Propofol is cleared mainly by UGT1A9 and by CYP2B6 and CYP2C9. Studies have linked CYP2B6 variants to its blood levels and the amount needed, and UGT1A9 to side effects; others looked at GABA receptor genes and ABCB1. The effects are small compared with age, weight and other medicines, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Propofol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
UGT1A9 rs58597806: Level 3. Toxicity. 1.
CYP2B6 rs3745274: Level 3. Dosage. 1.
ADRB2 rs1042718: Level 3. Toxicity: Hypotensive disorder. 1.
ABCB1 rs1128503: Level 3. Efficacy. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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