Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Proguanil is an antimalarial, a prodrug that the body turns into cycloguanil, which blocks the parasite's dihydrofolate reductase; proguanil itself also helps atovaquone work. It is mostly used combined with atovaquone (Malarone) to prevent and treat malaria in travellers.
Proguanil is activated to cycloguanil mainly by CYP2C19, and CYP2C19 poor metabolizers, more common in East Asian and Pacific populations, form little cycloguanil. Since atovaquone-proguanil works largely through proguanil itself and atovaquone, this matters less for the combination. Studies also looked at SLC22A1 for its uptake. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Proguanil. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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