Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pimozide is an older antipsychotic that blocks dopamine D2 receptors. It is used mainly for severe tics in Tourette's syndrome when other treatments have not helped, and in some countries for certain psychoses. It can affect the heart rhythm, so it is used with care. It is sold as Orap, among other names.
Pimozide is broken down by the liver enzymes CYP3A4 and CYP2D6. People with no working CYP2D6 copies (poor metabolizers) reach higher levels, and because high levels can lengthen the QT interval of the heartbeat, the US drug label discusses CYP2D6 genotyping. DPWG has published a guideline on CYP2D6 and pimozide, and the US FDA lists the pair. Only a few studies have looked at genes for this medicine.
Clinical guidelines that name a gene for Pimozide. They sort people into groups by the gene copies they carry.
DPWG guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. 2024.
US FDA: CYP2D6. CYP2D6 activity score 0.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Pimozide. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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