Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Perampanel is an anticonvulsant that blocks AMPA glutamate receptors, the first medicine of its kind. It is used once daily at bedtime for focal seizures and primary generalised tonic-clonic seizures. Mood and behaviour changes, including irritability and aggression, are known side effects. It is sold as Fycompa.
Perampanel is broken down mainly by CYP3A4 (with CYP3A5) and lasts a long time in the body. The gene studies on it, mostly from Japan, looked at CYP3A4 and CYP3A5 variants for its blood levels and response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Perampanel. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antiepileptics (class) (Anticonvulsants)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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