Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Antiepileptics (anti-seizure medications) are a class of medicines that make seizures less likely, by calming overactive nerve signalling: some block sodium or calcium channels, others strengthen the calming messenger GABA. The class includes carbamazepine, lamotrigine, valproate, levetiracetam, phenytoin and many others; several are also used for nerve pain or bipolar disorder. This page collects studies that looked at them as a group.
For the class as a whole, the clearest finding is HLA-B*15:02, linked to serious skin reactions with several sodium-channel blockers (carbamazepine, phenytoin, oxcarbazepine, lamotrigine), each with its own page and guideline. Studies of drug resistance have looked at transporters that pump medicines out of the brain (ABCB1, ABCC2, ABCG2) and at channel genes such as SCN1A, with mixed results.
Every published finding on gene variants and Antiepileptics. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HLA-B HLA-B*15:02: Level 2A · replicated. Toxicity: Maculopapular Exanthema, Severe Cutaneous Adverse Reactions, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis. 4.
ABCB1 rs2032582: Level 3. Dosage, Efficacy: Epilepsy. 4.
ABCB1 rs3789243: Level 3. Efficacy: Epilepsy. 2.
HLA-B HLA-B*58:01: Level 3. Toxicity: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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