Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Panitumumab is a biologic medicine, a fully human monoclonal antibody that blocks EGFR, a growth-signal receptor on many cancer cells. Given by drip every two weeks, it is used for advanced bowel cancer, alone or with chemotherapy. A skin rash is its typical side effect. It is sold as Vectibix.
Whether panitumumab works in bowel cancer depends on the tumour: it does not work when the cancer carries mutations in KRAS or NRAS, so tumour tissue is tested before treatment. Those mutations are acquired in the cancer, not inherited. For inherited genes, studies have looked at the EGFR ligands AREG, EREG and EGF and at the antibody receptor FCGR2A, with mixed results. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Panitumumab. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
KRAS rs61764370: Level 3. Efficacy: Neoplasms. 6.
AREG rs1353295: Level 3. Efficacy: Colorectal Neoplasms. 1.
AREG rs13104811: Level 3. Efficacy: Colorectal Neoplasms. 1.
EGFR rs712829: Level 3. Efficacy: Colorectal Neoplasms. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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