Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Osimertinib is a third-generation EGFR tyrosine kinase inhibitor designed to block both the common activating EGFR mutations and T790M, the mutation that makes earlier EGFR inhibitors stop working. It is used for EGFR-mutated non-small cell lung cancer, as first treatment, after surgery and after earlier EGFR inhibitors, and it reaches the brain well. It is sold as Tagrisso.
Whether osimertinib works depends on EGFR mutations in the tumour (exon 19 deletions, L858R, T790M), found by testing tumour tissue or tumour DNA in the blood; these are acquired in the cancer, not inherited. The single gene study listed looked at LZTR1 in tumours. Osimertinib is broken down mainly by CYP3A4. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Osimertinib. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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