Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a class of HIV medicines that bind reverse transcriptase near its active site and block it, so HIV cannot copy its genetic material into the cell's DNA. The class includes efavirenz, nevirapine, rilpivirine, etravirine and doravirine, always used with other HIV medicines. This page collects studies on NNRTIs as a group.
The key gene for the older NNRTIs is CYP2B6, which breaks down efavirenz and nevirapine: people with slow CYP2B6 versions, such as *6, reach much higher levels and more side effects. CPIC and DPWG have published guidelines on CYP2B6 and efavirenz, on its own page. The gene studies listed for the class concern CYP2B6.
Every published finding on gene variants and NNRTIs. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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