Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Etravirine is a second-generation NNRTI, an HIV medicine that binds reverse transcriptase flexibly enough to work against many viruses resistant to efavirenz and nevirapine. It is used with other HIV medicines in people whose virus has developed resistance. It is sold as Intelence.
Etravirine is broken down by CYP3A4, CYP2C9 and CYP2C19. The gene study listed linked CYP2C19 (and CYP2C9) variants to its levels, with slower versions giving higher exposure. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Etravirine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 rs4244285: Level 3. Metabolism/PK: HIV infectious disease. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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