Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sodium nitroprusside is a powerful vasodilator that releases nitric oxide, relaxing both arteries and veins within seconds. Given by continuous drip in intensive care, it lowers blood pressure rapidly in hypertensive emergencies and during some surgery, and helps in acute heart failure. Its breakdown releases cyanide, so the duration and amount are limited. It is sold as Nipride and Nitropress.
Nitroprusside breaks down in the blood, releasing nitric oxide and cyanide, which the liver converts to thiocyanate. The gene study listed looked at ACE for blood vessel responses to nitroprusside in research settings. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Nitroprusside. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ACE rs1799752: Level 3. Efficacy. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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