Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
BiDil is a fixed combination of two vasodilators: hydralazine, which relaxes arteries, and isosorbide dinitrate, a nitrate that relaxes veins and supplies nitric oxide. It is used, added to standard treatment, for heart failure, and was approved in the US in 2005 specifically for self-identified Black patients after a trial (A-HeFT) found a large benefit in that group.
Because the approval was based on self-identified race, researchers looked for genes that might explain the response. Sub-studies of the A-HeFT trial looked at GNB3, NOS3 and CYP11B2 (aldosterone synthase) and found some variants linked to benefit. Hydralazine itself is inactivated by NAT2, which has its own guideline on the hydralazine page. There is no CPIC or DPWG guideline for the combination.
Every published finding on gene variants and BiDil. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GNB3 rs5443: Level 3. Efficacy: Heart Failure. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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