Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Neomycin is an aminoglycoside antibiotic that is poorly absorbed from the gut and skin. It is used in creams, ointments and ear and eye drops for local infections, and by mouth to reduce gut bacteria before bowel surgery or in hepatic encephalopathy. It is rarely given by injection because of its toxicity.
As for all aminoglycosides, the key gene is MT-RNR1, in the DNA of mitochondria, inherited from the mother. Variants such as m.1555A>G (rs267606617) make aminoglycosides bind the mitochondrial ribosome and can cause permanent hearing loss, which matters most when neomycin is absorbed, for example from large wounds or long oral courses. CPIC has published a guideline on MT-RNR1 and aminoglycosides, which covers neomycin.
Clinical guidelines that name a gene for Neomycin. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Neomycin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MT-RNR1 rs267606617: Level 1A · replicated. Toxicity: Ototoxicity. 5.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Aminoglycosides (class) (Aminoglycosides)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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