Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Aminoglycosides are a class of antibiotics that bind bacterial ribosomes and make them misread genetic instructions. The class includes gentamicin, tobramycin, amikacin, streptomycin, neomycin and plazomicin, used for serious Gram-negative infections, sepsis, some tuberculosis and, inhaled, lung infections in cystic fibrosis. Kidney damage and hearing loss are their main risks. This page collects studies on aminoglycosides as a group.
The key gene for the whole class is MT-RNR1, in the DNA of mitochondria, which is inherited from the mother. Variants such as m.1555A>G (rs267606617), m.1494C>T and m.1095T>C make the mitochondrial ribosome resemble a bacterial one, so aminoglycosides can cause permanent hearing loss, sometimes after a single dose. CPIC has published a guideline on MT-RNR1 and aminoglycosides. Most consumer DNA chips do not read these mitochondrial positions reliably.
Every published finding on gene variants and Aminoglycosides. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MT-RNR1 rs267606617: Level 1A · replicated. Toxicity: Ototoxicity. 31.
MT-RNR1 rs267606619: Level 1A · replicated. Toxicity: Ototoxicity. 8.
MT-RNR1 rs267606618: Level 1A · replicated. Toxicity: Ototoxicity. 3.
MT-RNR1 rs1556422499: Level 3. Toxicity: Ototoxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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