Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Nefazodone is an antidepressant of the SARI group (serotonin antagonist and reuptake inhibitor): it blocks 5-HT2A serotonin receptors and weakly blocks serotonin reuptake. It was used for depression; because of rare but serious liver injury, it was withdrawn in most countries in the early 2000s and remains available only in a few, as a generic in the US.
Nefazodone is broken down by CYP3A4, which it also strongly blocks, and its active breakdown product mCPP is cleared by CYP2D6. The few gene studies listing it come from studies of several antidepressants and looked at FKBP5, HTR1B and ABCB1 for response and side effects. The findings are weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Nefazodone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
FKBP5 rs1360780: Level 3. Efficacy: Depression. 7.
HTR1B rs130058: Level 3. Toxicity: Depression. 1.
FKBP5 rs1360780: Level 3. Toxicity: Depression. 1.
ABCB1 rs2032582: Level 3. Toxicity: Depression. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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