Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Naloxone is an opioid antagonist: it pushes opioids off their receptors and blocks them, reversing an opioid overdose within minutes. It is given as a nasal spray or injection in emergencies, and is widely available to the public in many countries. It is also combined with buprenorphine (Suboxone) to discourage misuse. It is sold as Narcan, among other names.
Naloxone is cleared quickly by the liver, mainly by UGT enzymes. The few gene studies listing it looked at the opioid receptor gene OPRM1, the receptor naloxone blocks, and at COMT, mostly in research on opioid responses and in buprenorphine-naloxone treatment. The findings are weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Naloxone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
OPRM1 rs1799971: Level 3. Efficacy. 4.
OPRM1 rs1799971: Level 3. Toxicity: Erythema. 1.
COMT rs4680: Level 3. Toxicity: Vomiting. 1.
COMT rs4680: Level 3. Toxicity: Erythema. 1.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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