Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Mycophenolic acid is an immunosuppressant that blocks IMPDH, an enzyme lymphocytes depend on to make guanine, a DNA building block, so they cannot multiply. It is used with other medicines to prevent rejection after kidney, heart and liver transplants, and for lupus kidney disease and other autoimmune conditions. It is sold as Myfortic, and as the prodrug mycophenolate mofetil (CellCept).
Mycophenolic acid is cleared mainly by UGT1A9 (with UGT2B7 and others), passes into bile via ABCC2, and returns from the gut, which gives it a second peak in the blood. Studies have linked variants in UGT1A9, ABCC2, SLCO1B1 and SLCO1B3 to its levels, and IMPDH variants to response and side effects. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Mycophenolic Acid. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCC2 rs3740066: Level 3. Metabolism/PK: Organ Transplantation. 3.
SLCO1B1 rs2306283: Level 3. Metabolism/PK: Kidney Transplantation. 2.
UGT1A9 rs3832043: Level 3. Metabolism/PK: Kidney Transplantation. 1.
SLCO1B3 rs4149117: Level 3. Efficacy: Lung transplantation, overall survival. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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