Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Muraglitazar was an experimental dual PPAR-alpha and PPAR-gamma agonist, designed to improve both blood sugar and blood fats in type 2 diabetes. Development stopped in 2006 after an analysis of its trials showed more heart attacks, strokes and heart failure, and it was never marketed.
The few gene studies on muraglitazar came from its clinical trials and looked at ADRB1, EDN1 and REN, genes of blood pressure and fluid balance, for fluid retention (oedema), a known side effect of PPAR-gamma agonists. The findings come from a single study. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Muraglitazar. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ADRB1 rs1801253: Level 3. Toxicity: Diabetes Mellitus, Edema, Hyperlipidemias. 1.
EDN1 rs5370: Level 3. Toxicity: Diabetes Mellitus, Edema, Hyperlipidemias. 1.
REN rs2368564: Level 3. Toxicity: Diabetes Mellitus, Edema, Hyperlipidemias. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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