Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Medroxyprogesterone acetate is a progestin, a synthetic form of progesterone. As a three-monthly injection (Depo-Provera) it is a widely used contraceptive; as tablets (Provera) it treats irregular or heavy periods and protects the womb lining during menopausal oestrogen therapy; at high doses it has been used for some cancers.
Medroxyprogesterone is broken down mainly by CYP3A4. The gene studies listing it looked at ESR1 and VDR for bone effects with menopausal hormone therapy, and at CYP2B6 and NAT2, partly in women also taking HIV medicines such as efavirenz, which speed up its breakdown. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Provera. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ESR1 rs9340799: Level 3. Efficacy. 1.
VDR rs1544410: Level 3. Efficacy. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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