Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Lurasidone is an antipsychotic that blocks dopamine D2, serotonin 5-HT2A and 5-HT7 receptors and partly activates 5-HT1A receptors. It is used for schizophrenia and for depression in bipolar disorder, taken with food. It causes relatively little weight gain. It is sold as Latuda.
Lurasidone is broken down almost entirely by CYP3A4, so other medicines that block or speed up CYP3A4 change its levels far more than genes do. The few gene studies on it looked at the serotonin 5-HT1A receptor gene HTR1A for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Lurasidone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HTR1A rs6295: Level 3. Efficacy: Schizophrenia. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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