Lumefantrine

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Lumefantrine

What it is

Lumefantrine is a long-acting antimalarial that is always combined with artemether (as Coartem or Riamet). Artemether clears most parasites quickly, and lumefantrine, which stays in the blood for days, mops up the rest. It is one of the most used treatments for uncomplicated falciparum malaria worldwide, and is taken with fatty food for good absorption.

How genes come into it

Lumefantrine is broken down mainly by CYP3A4, with CYP3A5 contributing. Studies, many in African patients also taking HIV medicines, looked at CYP3A4, CYP3A5 and CYP2B6 variants, partly because efavirenz, whose levels depend on CYP2B6, speeds up lumefantrine's breakdown. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Lumefantrine. Upload your DNA file to see which of these rows apply to you.

Rated evidence (4 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

CYP3A5;ZSCAN25 rs776746: Level 3. Metabolism/PK: Malaria. 1.

CYP3A4 rs2740574: Level 3. Efficacy, Metabolism/PK: Malaria. 1.

CYP3A5 rs10264272: Level 3. Metabolism/PK: Malaria. 1.

CYP3A5 rs41303343: Level 4. Metabolism/PK: Malaria. 1.

Metabolism (10 findings)

Studies of how quickly the body processes this medication.

ABCC2 rs8187710: Genotype AA is associated with increased concentrations of lumefantrine in children with Malaria as compared to genotypes AG + GG.

CYP3A4 rs2740574: Allele C is associated with increased concentrations of lumefantrine in women with Malaria and Pregnancy as compared to allele T.

CYP3A5 rs10264272: Allele T is associated with increased concentrations of lumefantrine in women with Malaria and Pregnancy as compared to allele C.

CYP3A5 rs776746: Allele C is associated with increased concentrations of lumefantrine in women with Malaria and Pregnancy as compared to allele T.

Response (8 findings)

Studies of how well it worked in people carrying a variant.

CYP2B6 rs3745274: Genotype GT is associated with decreased clinical benefit to artemether and lumefantrine in people with Malaria as compared to genotypes GG + TT.

CYP3A4 rs2740574: Allele T is associated with decreased response to lumefantrine in women with Malaria and Pregnancy as compared to allele C.

ABCB1 rs3842: Allele T is not associated with response to lumefantrine in women with Malaria and Pregnancy as compared to allele C.

CYP2B6 rs28399499: Allele C is not associated with response to lumefantrine in women with Malaria and Pregnancy as compared to allele T.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Artemether (Antimalarials)

Artesunate (Antimalarials)

Chloroquine (Antimalarials)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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