Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid family, given as a prodrug that the body converts into its active form. It is one of the most used pain medicines in Japan, and is also sold in Brazil, Mexico and other countries, for pain, inflammation and fever; it is not available in the US or most of Europe. It is sold as Loxonin.
Loxoprofen is activated by carbonyl reductase and cleared by UGT enzymes. The gene studies listed, from Japan, looked at gene regions linked to NSAID side effects such as stomach injury and hypersensitivity. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Loxoprofen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
rs9933632: Level 3. Toxicity. 1.
rs6500265: Level 3. Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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