Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Liraglutide is a GLP-1 receptor agonist: it mimics the gut hormone GLP-1, which makes the pancreas release insulin when blood sugar is high, slows stomach emptying and reduces appetite. Injected once a day, it is used for type 2 diabetes (Victoza), where it also lowers the chance of heart attack and stroke, and for weight management (Saxenda).
As a peptide, liraglutide is broken down by enzymes throughout the body, not by liver CYP enzymes. Studies have looked mainly at GLP1R, the gene for the receptor it acts on, linking some variants to how much blood sugar or weight fell, and at CNR1 and TCF7L2. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Liraglutide. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GLP1R rs10305420: Level 3. Efficacy: Obesity, Polycystic Ovary Syndrome. 1.
GLP1R rs6923761: Level 3. Efficacy: Obesity, Polycystic Ovary Syndrome. 1.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
GLP-1 Agonists (class) (GLP-1 Agonists)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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