GLP-1 Agonists (class)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About GLP-1 Agonists

What it is

GLP-1 receptor agonists are a class of medicines that mimic the gut hormone GLP-1: they make the pancreas release insulin when blood sugar is high, slow stomach emptying and reduce appetite through the brain. The class includes semaglutide, liraglutide, dulaglutide and exenatide (tirzepatide also acts on the GIP receptor). They are used for type 2 diabetes, weight management and reducing cardiovascular risk. This page collects studies on the class as a group.

How genes come into it

GLP-1 agonists are peptides broken down like proteins, not by liver CYP enzymes. Studies of the class looked at GLP1R, the gene for their receptor, and ARRB1, involved in the receptor's signalling, for how much blood sugar and weight fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and GLP-1 Agonists. Upload your DNA file to see which of these rows apply to you.

Response (6 findings)

Studies of how well it worked in people carrying a variant.

ARRB1 rs140226575: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

ARRB1 rs58428187: Allele C is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele T.

ARRB1 rs78052828: Allele T is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele C.

ARRB1 rs78979036: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Byetta (GLP-1 Agonists)

Ozempic (GLP-1 Agonists)

Tanzeum (GLP-1 Agonists)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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