Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the same family as ibuprofen: it blocks the COX enzymes that make prostaglandins. It is used for arthritis, muscle and joint pain, period pain and pain after surgery, as capsules, injections and gels. It is sold as Orudis, Oruvail and Fastum, among other names.
Ketoprofen is cleared mainly by UGT enzymes, with only a small part handled by CYP2C9 and CYP3A4, so CYP2C9 variants matter less than for other NSAIDs; the CPIC guideline on NSAIDs does not cover it. Studies have looked at CYP2C9 and at its targets, PTGS1 and PTGS2 (COX-1 and COX-2), for pain relief and side effects. The findings come from a few studies.
Every published finding on gene variants and Ketoprofen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2: Level 3. Toxicity: Dyspepsia, Pain, Postoperative. 1.
CYP2C9 CYP2C9*1, CYP2C9*3: Level 3. Efficacy: Pain, Postoperative. 1.
CYP2D6 CYP2D6*1, CYP2D6*2, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*9, CYP2D6*10, CYP2D6*17, CYP2D6*41: Level 3. Toxicity. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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