Irbesartan (Avapro)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Irbesartan

What it is

Irbesartan is an angiotensin II receptor blocker (ARB): it stops angiotensin II from narrowing blood vessels and making the body hold salt. It is used for high blood pressure and to protect the kidneys in people with type 2 diabetes and kidney disease. It is sold as Avapro and Aprovel, among other names.

How genes come into it

Irbesartan is broken down mainly by the liver enzyme CYP2C9, and studies have linked reduced-function versions such as *3 to higher levels and, in some, a larger drop in blood pressure. Others looked at genes of the renin-angiotensin system (AGT, ACE, AGTR1, CYP11B2) and at EDN1 and APOB for blood pressure response, with weaker evidence. There is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Irbesartan. Upload your DNA file to see which of these rows apply to you.

Rated evidence (10 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

AGT rs699: Level 3. Efficacy: Hypertension, Hypertrophy, Left Ventricular. 4.

AGTR1 rs5186: Level 3. Efficacy: Hypertension, Hypertrophy, Left Ventricular. 3.

AGT rs4762: Level 3. Efficacy: Hypertension, Hypertrophy, Left Ventricular. 2.

ACE rs1799752: Level 3. Efficacy: Hypertension, Hypertrophy, Left Ventricular. 2.

Metabolism (7 findings)

Studies of how quickly the body processes this medication.

CYP2C9 rs1057910: Genotype AC is associated with decreased clearance of irbesartan in healthy individuals as compared to genotype AA.

CYP2C9 rs1057910: Genotype AC is associated with decreased metabolism of irbesartan in healthy individuals as compared to genotype AA.

CYP2C9 rs1057910: Genotype AC is associated with increased concentrations of irbesartan in healthy individuals as compared to genotype AA.

CYP2C9 rs1057910: Genotype AC is associated with increased concentrations of irbesartan in people with Essential hypertension as compared to genotype AA.

Response (24 findings)

Studies of how well it worked in people carrying a variant.

ACE rs1799752: Genotype ATACAGTCACTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCC/ATACAGTCACTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCC is associated with increased response to irbesartan in people with Hypertension as compared to genotypes ATACAGTCACTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCC/del + del/del.

AGT rs4762: Genotype AG is associated with increased response to atenolol or irbesartan in people with Hypertrophy, Left Ventricular as compared to genotype GG.

AGT rs699: Genotype GG is associated with increased response to irbesartan in people with Hypertrophy, Left Ventricular as compared to genotypes AA + AG.

AGT rs699: Genotypes AG + GG are associated with increased response to irbesartan in people with Hypertrophy, Left Ventricular as compared to genotype AA.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

ARBs (class) (ARBs)

Atacand (ARBs)

Cozaar (ARBs)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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