Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Candesartan is an angiotensin II receptor blocker (ARB): it stops angiotensin II from narrowing blood vessels and making the body hold salt. It is used for high blood pressure and heart failure, and sometimes to prevent migraine. It is sold as Atacand and Amias, among other names.
Candesartan is given as a prodrug that is activated in the gut wall and cleared mostly unchanged by the kidneys and bile, with only a small part broken down by CYP2C9. Studies have looked at the receptor gene AGTR1, at CYP11B2 (aldosterone synthase), and at genes flagged by genome-wide studies (SH2B3, KCNK3 and others) for how much blood pressure fell. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Candesartan. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP11B2 rs1799998: Level 3. Efficacy: Hypertension. 1.
AGTR1 rs5186: Level 3. Efficacy: Heart Failure. 1.
GPR83 rs3758785: Level 3. Efficacy: Essential hypertension. 1.
KCNK3 rs1275988: Level 3. Efficacy: Hypertension. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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