Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Indomethacin (indometacin) is a potent non-steroidal anti-inflammatory drug (NSAID) that blocks the COX enzymes making prostaglandins. It is used for gout attacks, ankylosing spondylitis, some rare headache types that respond only to it, and in premature babies to close the ductus arteriosus, a blood vessel that should close after birth. It is sold as Indocin, among other names.
Indomethacin is broken down by CYP2C9 and UGT enzymes. Studies have looked at CYP2C9 variants for its levels and side effects, and at inflammation genes (IL1B, TNF, IL6) for pain relief. CPIC reviewed indomethacin in its NSAID guideline but did not find enough evidence for a recommendation. The findings come from a few studies.
Every published finding on gene variants and Indomethacin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*3: Level 3. Toxicity. 2.
LST1;LTA;TNF rs1800629: Level 3. Efficacy: Migraine without Aura. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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