Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Iloperidone is an antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors. It is used for schizophrenia and, more recently, for mania or mixed episodes in bipolar I disorder. It is started slowly to limit dizziness on standing. It is sold as Fanapt.
Iloperidone is broken down by the liver enzymes CYP2D6 and CYP3A4. People with no working CYP2D6 copies (poor metabolizers) have clearly higher levels of iloperidone and its active breakdown product, and since higher levels can lengthen the QT interval of the heartbeat, the US drug label addresses CYP2D6 poor metabolizers. The US FDA lists the pair; there is no CPIC or DPWG guideline. A small genome-wide study looked at genes linked to QT changes, with weak evidence.
Clinical guidelines that name a gene for Iloperidone. They sort people into groups by the gene copies they carry.
US FDA: CYP2D6. CYP2D6 activity score 0. 2025.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Iloperidone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 rs1065852: Level 3. Toxicity: Schizophrenia. 1.
NRG3 rs4933824: Level 3. Toxicity: Acquired Long QT Syndrome (aLQTS). 1.
NUBPL rs7142881: Level 3. Toxicity: Acquired Long QT Syndrome (aLQTS). 1.
CELF4 rs4799915: Level 3. Toxicity: Acquired Long QT Syndrome (aLQTS). 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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