Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Iguratimod is a disease-modifying antirheumatic drug (DMARD) that suppresses the production of inflammatory signals and antibodies, partly by blocking NF-kappaB. It is used for rheumatoid arthritis in Japan and China, often with methotrexate; it is not approved in Europe or the US. It is sold as Careram and Kolbet.
Iguratimod is broken down in the liver, partly by CYP2C9 and CYP3A4. The gene studies listed, from China, looked at ABCB1, ABCG2 and NAT2 for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Iguratimod. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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