Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Hydroxychloroquine is an antimalarial that also calms the immune system, by interfering with how immune cells process signals inside their lysosomes. Today it is used mostly for lupus and rheumatoid arthritis, and still for some kinds of malaria. Long-term use needs regular eye checks. It is sold as Plaquenil, among other names.
The US FDA lists G6PD for hydroxychloroquine, because antimalarials of this family can cause haemolysis, the breakdown of red blood cells, in people with G6PD deficiency, although with hydroxychloroquine this appears rare. It is broken down by CYP2C8, CYP2D6 and CYP3A4. There is no CPIC or DPWG guideline, and the studies on this page, on these enzymes and on immune and folate genes in rheumatoid arthritis, are single findings.
Clinical guidelines that name a gene for Hydroxychloroquine. They sort people into groups by the gene copies they carry.
US FDA: G6PD. Deficient with CNSHA · Deficient · Variable.
Every published finding on gene variants and Hydroxychloroquine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MTR rs1805087: Level 3. Efficacy: Rheumatoid arthritis. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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