Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Highly active antiretroviral therapy (HAART, now usually called ART or cART) is the treatment of HIV with a combination of at least three antiretroviral medicines from two or more groups. Introduced in 1996, it turned HIV from a fatal disease into a manageable long-term condition; taken consistently, it keeps the virus undetectable and stops it from being passed on. This page collects studies on combination treatment as a whole.
Studies of combination treatment as a whole looked at ABCB1, OPRM1 and the IFNL3 region for response in people also treated for other conditions. The strongest gene findings belong to individual medicines, each on its own page: HLA-B*57:01 for abacavir, CYP2B6 for efavirenz and UGT1A1 for atazanavir, all with guidelines.
Every published finding on gene variants and HAART. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs1045642: Level 3. Efficacy: HIV infectious disease. 1.
OPRM1 rs671531: Level 3. Efficacy: HIV infectious disease. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
HIV Antivirals (class) (Antiretrovirals)
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com