Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
HIV is treated with combinations of antiretroviral medicines (antiretroviral therapy, ART), usually two or three drugs from different groups, often in a single daily tablet: nucleoside reverse transcriptase inhibitors such as tenofovir and emtricitabine, integrase inhibitors such as dolutegravir and bictegravir, and others. Taken consistently, they keep the virus undetectable and stop it from being passed on. This page collects studies on HIV combinations as a group.
Studies of combination treatment looked at CYP2B6, NAT2 and ABCB1 for side effects, and at genes of fat metabolism for raised blood lipids. The strongest gene findings belong to individual medicines with their own pages and guidelines: HLA-B*57:01 for abacavir, CYP2B6 for efavirenz, and UGT1A1 for atazanavir.
Every published finding on gene variants and HIV Antivirals. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
APOE rs7412: Level 3. Toxicity: HIV infectious disease, Hyperlipidemias, Hypertriglyceridemia. 2.
APOE rs7412: Level 3. Toxicity: HIV infectious disease, Hypertriglyceridemia. 2.
ABCB1 rs1045642: Level 3. Toxicity: HIV infectious disease, Tuberculosis. 1.
CYP2B6 rs3745274: Level 3. Toxicity: HIV infectious disease, Tuberculosis. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
HAART (class) (Antiretrovirals)
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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