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Albiglutide (Tanzeum)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Albiglutide

What it is

Albiglutide is a GLP-1 receptor agonist made of two GLP-1 copies fused to human albumin, which lets it last a week. It mimics the gut hormone GLP-1 to lower blood sugar in type 2 diabetes, and in a large trial reduced cardiovascular events. It was withdrawn from the market in 2018 for commercial reasons. It was sold as Tanzeum and Eperzan.

How genes come into it

As a protein, albiglutide is broken down like other proteins, not by liver enzymes. The gene studies on it looked at GLP1R, the gene for its receptor, and ARRB1, involved in the receptor's signalling, for how much blood sugar fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Albiglutide. Upload your DNA file to see which of these rows apply to you.

Response (6 findings)

Studies of how well it worked in people carrying a variant.

ARRB1 rs140226575: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

ARRB1 rs58428187: Allele C is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele T.

ARRB1 rs78052828: Allele T is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele C.

ARRB1 rs78979036: Allele A is associated with increased clinical benefit to albiglutide, dulaglutide or Glucagon-like peptide-1 (GLP-1) analogues in people with Diabetes Mellitus, Type 2 as compared to allele G.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Byetta (GLP-1 Agonists)

GLP-1 Agonists (class) (GLP-1 Agonists)

Ozempic (GLP-1 Agonists)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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