Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Gliclazide is a sulfonylurea: it closes potassium channels in the insulin-making beta cells of the pancreas, which makes them release more insulin and lowers blood sugar. It is widely used for type 2 diabetes in Europe, Asia and Australia, but not marketed in the US. It is sold as Diamicron, among other names.
Gliclazide is broken down mainly by CYP2C9, with a part by CYP2C19, and studies have linked variants in both to its levels. Others looked at KCNJ11 and ABCC8, which make the channel it closes, and at KCNQ1, a diabetes gene, for how much blood sugar fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Gliclazide. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
KCNJ11 rs5219: Level 3. Efficacy: Diabetes Mellitus. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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