Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Gabapentin is a gabapentinoid: despite its name it does not act on GABA receptors, but binds the alpha-2-delta subunit of calcium channels in nerve cells, reducing the release of excitatory messengers. It is used for nerve pain, such as after shingles or in diabetes, for focal seizures, and for restless legs syndrome. It is sold as Neurontin and Gralise, among other names.
Gabapentin is not broken down at all; the kidneys clear it unchanged, so drug-processing genes play no part. It is absorbed from the gut by an amino acid transporter, and studies looked at SLC7A5 (LAT1), which carries it across the blood-brain barrier, and at GABA receptor genes for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Gabapentin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC7A5 rs4240803: Level 3. Toxicity: adverse events, Neuropathic pain. 1.
SLC7A5 rs4240803: Level 3. Efficacy: Neuropathic pain. 1.
SLC7A5 rs4240803: Level 3. Dosage: Neuropathic pain. 1.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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