Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) of the same family as ibuprofen: it blocks the COX enzymes that make prostaglandins, the signals behind pain and inflammation. It is used for arthritis pain, as lozenges for sore throat, and as eye drops during eye surgery. It is sold as Ansaid, Strefen and Ocufen, among other names.
Flurbiprofen is broken down mainly by the liver enzyme CYP2C9. People with reduced-function versions such as *3, and especially poor metabolizers with two of them, clear it more slowly and have higher levels. CPIC has published a guideline on CYP2C9 and the NSAIDs, including flurbiprofen, and the US drug label addresses CYP2C9 poor metabolizers.
Clinical guidelines that name a gene for Flurbiprofen. They sort people into groups by the gene copies they carry.
CPIC guideline: CYP2C9. CYP2C9 activity score 0 to 2. Strong. 2020.
US FDA: CYP2C9. CYP2C9 activity score 0 to 0.5.
Every published finding on gene variants and Flurbiprofen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3, CYP2C9*29: Level 1A · replicated. Metabolism/PK. 3.
CYP2C9 rs780801862: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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