Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Flupentixol (flupenthixol) is a first-generation thioxanthene antipsychotic that blocks dopamine D1 and D2 receptors. At higher doses and as a long-acting injection it is used for schizophrenia; at low doses, in some countries, for depression, sometimes combined with melitracen. It is sold as Fluanxol and Depixol, and is not marketed in the US.
Flupentixol is broken down in the liver, partly by CYP2D6. The gene studies listed, from China and mostly concerning the flupentixol-melitracen combination, looked at NFKB1. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Flupenthixol. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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