Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluoxetine was one of the first SSRI antidepressants: it keeps more of the messenger serotonin available between nerve cells. It is used for depression, obsessive-compulsive disorder, bulimia, panic disorder and severe premenstrual symptoms. It and its active breakdown product stay in the body for weeks. It is sold as Prozac and Sarafem, among other names.
The liver enzyme CYP2D6 breaks fluoxetine down into norfluoxetine, which is also active, and fluoxetine blocks CYP2D6 strongly as it builds up. CYP2D6 poor metabolizers have higher fluoxetine levels, which the US FDA lists for the pair, but because the two forms together act much the same, there is no CPIC or DPWG recommendation to change treatment. Many studies have looked at serotonin genes such as HTR2A and SLC6A4 for how well it works, with weaker evidence.
Clinical guidelines that name a gene for Fluoxetine. They sort people into groups by the gene copies they carry.
US FDA: CYP2D6. CYP2D6 activity score 0.
Every published finding on gene variants and Fluoxetine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*1xN, CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*10, CYP2D6*17: Level 3. Metabolism/PK: Major Depressive Disorder, Mental Disorders. 10.
SLC6A4 rs57098334: Level 3. Efficacy: Depression, Major Depressive Disorder. 4.
ABCB1 rs4148739: Level 3. Efficacy: Depression, Major Depressive Disorder. 2.
HTR1A rs6295: Level 3. Efficacy: Major Depressive Disorder. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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