Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluindione is a vitamin K antagonist anticoagulant of the indanedione family, used mainly in France, where it was long the most prescribed oral anticoagulant, under the name Previscan. Like warfarin, it blocks vitamin K from doing its part in making clotting factors, and its effect is monitored with the INR blood test.
As with warfarin, VKORC1 makes the enzyme fluindione blocks, and the common variant rs9923231 makes less of it, so less fluindione has the same effect; CYP2C9 also contributes to its clearance. The gene studies listed, from France, looked at VKORC1 and CYP2C9. The findings come from a few studies, and there is no CPIC or DPWG guideline for fluindione.
Every published finding on gene variants and Fluindione. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
VKORC1 rs9934438: Level 3. Efficacy: Thromboembolism. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Acenocoumarol (Anticoagulants)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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