Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Acenocoumarol is a coumarin anticoagulant, a close relative of warfarin: it blocks vitamin K from doing its part in making clotting factors, so blood takes longer to clot. It is used, mainly in parts of Europe and Latin America, to prevent and treat blood clots and to lower the chance of stroke in atrial fibrillation. It is sold as Sintrom, among other names.
The same genes that shape warfarin treatment shape acenocoumarol. VKORC1 makes the enzyme it blocks, and the common variant rs9923231 makes less of it, so less acenocoumarol has the same effect. CYP2C9 breaks it down, and its *2 and *3 versions slow that; CYP4F2 plays a smaller part. DPWG has published a guideline on VKORC1 and acenocoumarol, and well over a hundred studies have looked at these and other genes.
Clinical guidelines that name a gene for Acenocoumarol. They sort people into groups by the gene copies they carry.
DPWG guideline: VKORC1. rs9923231 C/C · rs9923231 T/T · rs9923231 C/T. 2011.
Every published finding on gene variants and Acenocoumarol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
VKORC1 rs9923231: Level 1A · replicated. Dosage. 20.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3: Level 1B · replicated. Dosage. 35.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3: Level 1B · replicated. Toxicity: over-anticoagulation. 15.
CYP4F2 rs2108622: Level 2A · replicated. Dosage: Atrial Fibrillation. 14.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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