Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fenofibrate is a fibrate: it activates PPAR-alpha, a switch in liver and muscle cells that speeds up fat burning, which lowers triglycerides and somewhat raises HDL cholesterol. It is used for high triglycerides and mixed blood fat disorders, usually alongside diet. It is sold as Tricor, Lipofen and Lipanthyl, among other names.
Fenofibrate is cleared mainly by UGT enzymes, not by the CYP enzymes, and no gene has strong evidence for it. Studies have looked at genes of fat transport for how much triglycerides fell, such as APOA5, APOA1, APOC3 and APOA4, at its target PPARA, and at inflammation markers such as CRP. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Fenofibrate. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
APOA5 rs3135506: Level 3. Efficacy: Hypertriglyceridemia. 3.
ABCA1 rs2230806: Level 3. Efficacy: Hypertriglyceridemia. 1.
CRP rs3091244: Level 3. Efficacy: Metabolic Syndrome. 1.
IL6 rs1800795: Level 3. Efficacy: Cardiovascular Disease. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antithyroid Drugs (class) (Antithyroid Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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