Febuxostat (Uloric)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Febuxostat

What it is

Febuxostat lowers uric acid by blocking xanthine oxidase, the enzyme that makes it, like allopurinol but with a different, non-purine structure. It is used for long-term treatment of gout, mainly when allopurinol cannot be used. It is sold as Uloric and Adenuric.

How genes come into it

Febuxostat is cleared mainly by UGT enzymes and partly by CYP enzymes. Unlike allopurinol, it has no known link to HLA-B*58:01. The few gene studies on it looked at AOX1, the UGT1A cluster and its target XDH for how much febuxostat people needed. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Febuxostat. Upload your DNA file to see which of these rows apply to you.

Rated evidence (3 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

AOX1 rs75995567: Level 3. Dosage: Gout. 1.

AOX1 rs3731722: Level 3. Dosage: Gout. 1.

UGT1A1;UGT1A10;UGT1A3;UGT1A4;UGT1A5;UGT1A6;UGT1A7;UGT1A8;UGT1A9 rs34650714: Level 3. Dosage: Gout. 1.

Dosing (5 findings)

Studies of how much of the drug people needed or tolerated.

AOX1 rs11678615: Allele T is associated with dose of allopurinol or febuxostat in people with Gout as compared to allele C.

AOX1 rs3731722: Allele G is associated with dose of allopurinol or febuxostat in people with Gout as compared to allele A.

AOX1 rs75995567: Allele T is associated with increased dose of allopurinol or febuxostat in people with Gout as compared to allele C.

UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9 rs34650714: Allele T is associated with decreased dose of allopurinol or febuxostat in people with Gout as compared to allele C.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Zyloprim (Xanthine Oxidase Inhibitors)

Actonel (Bisphosphonates)

Advil (NSAIDs)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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