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Erythropoietin (Epogen)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Erythropoietin

What it is

Erythropoietin (EPO) is the kidney hormone that tells the bone marrow to make red blood cells; as a medicine it is made by recombinant technology (epoetin alfa and related forms). It is injected to treat anaemia in chronic kidney disease, anaemia caused by chemotherapy, and in some other settings. It is sold as Epogen, Procrit, Eprex and others.

How genes come into it

As a protein hormone, erythropoietin is cleared by binding to its receptor rather than by liver enzymes. The few gene studies on it looked at HFE, the main gene of hereditary haemochromatosis, for how much epoetin people on dialysis needed, and at ORAI1 and STIM1. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Erythropoietin. Upload your DNA file to see which of these rows apply to you.

Response (2 findings)

Studies of how well it worked in people carrying a variant.

ORAI1 rs12320939: Genotypes GG + GT is associated with increased resistance to erythropoietin in people with Kidney Diseases and Anemia as compared to genotype TT.

STIM1 rs1561876: Genotypes AG + GG is associated with increased resistance to erythropoietin in people with Kidney Diseases and Anemia as compared to genotype AA.

Dosing (2 findings)

Studies of how much of the drug people needed or tolerated.

HFE rs1799945: Allele G is associated with decreased dose of epoetin alfa in people with hemodialysis treatment as compared to allele C.

HFE rs1800562: Allele A is associated with decreased dose of epoetin alfa in people with hemodialysis treatment as compared to allele G.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

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Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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