Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Erythromycin is a macrolide antibiotic: it binds bacterial ribosomes and stops them from making proteins. It is used for chest, skin and other infections, especially in people allergic to penicillin, as eye ointment for newborns, and at low doses to speed up stomach emptying. It strongly blocks CYP3A4, so it interacts with many medicines. It is sold as E-Mycin, Ery-Tab and Erythrocin, among other names.
Erythromycin is broken down by CYP3A4, and it has been used as a test substance to measure CYP3A4 activity (the erythromycin breath test). The few gene studies on it looked at CYP3A4, CYP3A5 and ABCC2 for its clearance. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Erythromycin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP3A4 rs35599367: Level 3. Other: Neoplasms. 1.
ABCC2 rs717620: Level 3. Other. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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